Bacterial selenocysteine synthase structure revealed by single-particle cryoEM
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ABSTRACT:
SUBMITTER: Vitor Hugo Balasco Serrao
PROVIDER: EMPIAR-12043 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Bacterial selenocysteine synthase structure revealed by single-particle cryoEM.
Balasco Serrão Vitor Hugo VH Minari Karine K Pereira Humberto D'Muniz HD Thiemann Otavio Henrique OH
Current research in structural biology 20240416
The 21st amino acid, selenocysteine (Sec), is synthesized on its dedicated transfer RNA (tRNA<sup>Sec</sup>). In bacteria, Sec is synthesized from Ser-tRNA<sup>[Ser]Sec</sup> by Selenocysteine Synthase (SelA), which is a pivotal enzyme in the biosynthesis of Sec. The structural characterization of bacterial SelA is of paramount importance to decipher its catalytic mechanism and its role in the regulation of the Sec-synthesis pathway. Here, we present a comprehensive single-particle cryo-electron ...[more]
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