Ontology highlight
ABSTRACT:
SUBMITTER: Han B
PROVIDER: S-EPMC7821874 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Han Bing B Porta Jason C JC Hanks Jessica L JL Peskova Yelena Y Binshtein Elad E Dryden Kelly K Claxton Derek P DP Mchaourab Hassane S HS Karakas Erkan E Ohi Melanie D MD Kenworthy Anne K AK
Science advances 20201202 49
Highly stable oligomeric complexes of the monotopic membrane protein caveolin serve as fundamental building blocks of caveolae. Current evidence suggests these complexes are disc shaped, but the details of their structural organization and how they assemble are poorly understood. Here, we address these questions using single particle electron microscopy of negatively stained recombinant 8S complexes of human caveolin 1. We show that 8S complexes are toroidal structures ~15 nm in diameter that co ...[more]