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Hypopseudouridylated yeast 80S bound with Taura syndrome virus (TSV) internal ribosome entry site (IRES) [ three datasets, in TIF format]

ABSTRACT:

SUBMITTER: Hong Li

PROVIDER: EMPIAR-12070 | biostudies-other |

REPOSITORIES: biostudies-other

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Regulation of translation by ribosomal RNA pseudouridylation.

Zhao Yu Y Rai Jay J Li Hong H

Science advances 20230818 33

Pseudouridine is enriched in ribosomal, spliceosomal, transfer, and messenger RNA and thus integral to the central dogma. The chemical basis for how pseudouridine affects the molecular apparatus such as ribosome, however, remains elusive owing to the lack of structures without this natural modification. Here, we studied the translation of a hypopseudouridylated ribosome initiated by the internal ribosome entry site (IRES) elements. We analyzed eight cryo-electron microscopy structures of the rib ...[more]

PMID: 37595043

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