Full-length mouse 5-HT3A receptor in complex with SMP100, pre-activated and open-like
Ontology highlight
ABSTRACT:
SUBMITTER: Kevin Christopher Felt
PROVIDER: EMPIAR-12199 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for partial agonism in 5-HT<sub>3A</sub> receptors.
Felt Kevin K Stauffer Madeleine M Salas-Estrada Leslie L Guzzo Peter R PR Xie Dejian D Huang Jinkun J Filizola Marta M Chakrapani Sudha S
Nature structural & molecular biology 20240104 4
Hyperactivity of serotonin 3 receptors (5-HT<sub>3</sub>R) underlies pathologies associated with irritable bowel syndrome and chemotherapy-induced nausea and vomiting. Setrons, a class of high-affinity competitive antagonists, are used in the treatment of these conditions. Although generally effective for chemotherapy-induced nausea and vomiting, the use of setrons for treating irritable bowel syndrome has been impaired by adverse side effects. Partial agonists are now being considered as an alt ...[more]
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