Movies of CagY∆AP mutant Cag T4SS from Helicobacter pylori
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ABSTRACT:
SUBMITTER: Jacquelyn Renee Roberts
PROVIDER: EMPIAR-12232 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Subdomains of the <i>Helicobacter pylori</i> Cag T4SS outer membrane core complex exhibit structural independence.
Roberts Jacquelyn R JR Tran Sirena C SC Frick-Cheng Arwen E AE Bryant Kaeli N KN Okoye Chiamaka D CD McDonald W Hayes WH Cover Timothy L TL Ohi Melanie D MD
Life science alliance 20240417 6
The <i>Helicobacter pylori</i> Cag type IV secretion system (Cag T4SS) has an important role in the pathogenesis of gastric cancer. The Cag T4SS outer membrane core complex (OMCC) is organized into three regions: a 14-fold symmetric outer membrane cap (OMC) composed of CagY, CagX, CagT, CagM, and Cag3; a 17-fold symmetric periplasmic ring (PR) composed of CagY and CagX; and a stalk with unknown composition. We investigated how CagT, CagM, and a conserved antenna projection (AP) region of CagY co ...[more]
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