Spatial multiomic insights into acute cocaine exposure

ABSTRACT: Despite extensive research on the subject, a comprehensive understanding of the molecular events occurring within the reward system following acute and chronic cocaine use has been lacking. In this study, we propose to employ a novel analytical workflow that combines high-resolution mass spectrometry imaging of the brain with region-specific microscale proteomics to reveal the molecular consequences of cocaine exposure on the principal areas of the reward system. We will employ a unique molecular imaging system, recently established at the Hebrew University, called Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI), to spatially map hundreds of metabolites, neurotransmitters and lipids in the reward system. This will be coupled with newly developed region-specific micr

ORGANISM(S): Mus musculus (mouse)

SUBMITTER:  

PROVIDER: S-BSST1255 | biostudies-other |

REPOSITORIES: biostudies-other