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Causal Relationship between the Gut Microbiota, Immune Cells, and Coronary Heart Disease: A Mediated Mendelian Randomization Analysis

ABSTRACT: Background: Recent studies have shown that gut microbiota (GM), immune cells, and coronary heart disease (CHD) are closely related, but the causal nature is largely unknown. This study aimed to investigate this causal relationship and to reveal the effect of GM, immune cells on the risk of developing CHD using mediated Mendelian randomization (MR) analysis. Methods: Firstly, we looked for the data related to GM, immune cells, and CHD through published genome-wide association studies (GWAS), filtered the SNPs (single nucleotide polymorphisms) related to GM and immune cells, and then performed the first MR analysis to get the disease-associated intestinal bacteria and disease-associated immune cells. Then, three MR analyses were performed: disease-associated GM to disease-associated immune cells, disease-associated immune cells to disease, and disease-associated GM to disease. Each MR analysis was performed using inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted models, and simple models. Results: 6 GM and 25 immune cells were associated with CHD. P < 0.05 and OR > 1 for the IVW method in the MR analysis of g__Desulfovibrio.s__Desulfovibrio_piger to EM DN (CD4−CD8−) %T cell, P < 0.05 and OR < 1 for the IVW method in the MR analysis of EM DN (CD4−CD8−) %T cell to CHD, and P < 0.05 and OR < 1 for the IVW method in the MR analysis of g__Desulfovibrio.s__Desulfovibrio_piger to CHD. Conclusion: An increase in the amount of g__Desulfovibrio.s__Desulfovibrio_piger leads to an increase in the amount of EM DN (CD4−CD8−) %T cell and an increase in the amount of EM DN (CD4−CD8−) %T cell reduces the risk of developing CHD. Our study provides some reference for reducing the incidence of coronary heart disease by regulating GM and immune cells.

ORGANISM(S): Homo sapiens (human)

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PROVIDER: S-BSST1516 | biostudies-other |

SECONDARY ACCESSION(S): 10.3389/fmicb.2024.1449935

REPOSITORIES: biostudies-other

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Causal Relationship between the Gut Microbiota, Immune Cells, and Coronary Heart Disease: A Mediated Mendelian Randomization Analysis

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