Translational Reprogramming as a Driver of Antimony-drug Resistance

ABSTRACT: Drug resistance is a major mitigating factor for leishmaniasis treatment, resulting in reduced therapeutic efficacy of pentavalent antimonials, the main antileishmanial drug. Nevertheless, the molecular mechanisms modulating the antimony-resistant phenotypes remain poorly understood. Since Leishmania parasites have limited use of transcriptional control, post-transcriptional mechanisms take a prominent role in the coordination of gene expression. Here, we used a translatomic approach, coupling polysome profiling and deep RNA-sequencing to determine if the resistance to antimony is modulated at the translational level. The translatome of the antimony-resistant strain (HR) was dramatically different from the sensitive strain (WT) even in the absence of the drug and included 2431 differentia

ORGANISM(S): Leishmania tropica

SUBMITTER:  

PROVIDER: S-BSST850 | biostudies-other |

SECONDARY ACCESSION(S): https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE173848

REPOSITORIES: biostudies-other