Association of Leptin and Leptin receptor Gene Polymorphisms with Insulin Resistance in Pregnant Women: A Cross-Sectional Study

ABSTRACT: Introduction: The objective of the study was to find the association between leptin/LEPR gene polymorphism and insulin resistance, in order to find the extent of risk of leptin gene polymorphism in causing insulin resistance in pregnant women. Methodology: Two hundred and eight pregnant women participated in this cross-sectional study of which 74 were insulin resistant cases and 134 were insulin sensitive controls. Genotyping of leptin and its receptor gene was carried out using the PCR-RFLP method. Serum levels of leptin, insulin, and C peptide were assayed using ELISA. Statistical analysis was carried out using SPSS 23. Results: Insignificant association was observed between leptin receptor gene polymorphisms and insulin resistance (chi-square=0.1275 p=0.721) and leptin gene and insulin-

ORGANISM(S): Homo sapiens (human)

SUBMITTER:  

PROVIDER: S-BSST854 | biostudies-other |

SECONDARY ACCESSION(S): S-EPMC6266652

REPOSITORIES: biostudies-other