Bortezomib resistance in THP-1 cell line

ABSTRACT: Bortezomib is a proteasome inhibitor used in severel different hematological malignancies. Resistance to this drug is still poorly understood. In order get more insight in the resistance mechanism, we developed several bortezomib resistant subclones of the THP-1 monocytic/macrophage cell line. On these subclones expression arrays were performed. We performed expression array three different bortezomib resistant subclones of the THP-1 cell line. The resistant subclones were spotted against the parental THP-1 wildtype cell line.

ORGANISM(S): Homo sapiens

SUBMITTER: Oerlemans R 

PROVIDER: S-ECPF-GEOD-11771 | biostudies-other | 2008 Sep

REPOSITORIES: biostudies-other