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Estrogen-like activity and dual roles in cell signaling of brefeldin A

ABSTRACT: Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA) Two-condition experiment, E2- or BFA-treated vs. control cells. Two biological replicates, independently grown and harvested. Two replicates per array.

ORGANISM(S): Homo sapiens

SUBMITTER: yun zhu

PROVIDER: S-ECPF-GEOD-33851 | biostudies-other |

REPOSITORIES: biostudies-other

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Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA) Two-condition experiment, E2- or BFA-treated vs. control cells. Two biological replicates, independently grown and harvested. Two replicates per array.

2014-01-01 | E-GEOD-33851 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of brefeldin A

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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

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Dual roles for LUBAC signaling in thymic epithelial cell development and survival.

Project description:Thymic epithelial cells (TECs) form a unique microenvironment that orchestrates T cell differentiation and immunological tolerance. Despite the importance of TECs for adaptive immunity, there is an incomplete understanding of the signalling networks that support their differentiation and survival. We report that the linear ubiquitin chain assembly complex (LUBAC) is essential for medullary TEC (mTEC) differentiation, cortical TEC survival and prevention of premature thymic atrophy. TEC-specific loss of LUBAC proteins, HOIL-1 or HOIP, severely impaired expansion of the thymic medulla and AIRE-expressing cells. Furthermore, HOIL-1-deficiency caused early thymic atrophy due to Caspase-8/MLKL-dependent apoptosis/necroptosis of cortical TECs. By contrast, deficiency in the LUBAC component, SHARPIN, caused relatively mild defects only in mTECs. These distinct roles for LUBAC components in TECs correlate with their function in linear ubiquitination, NFκB activation and cell survival. Thus, our findings reveal dual roles for LUBAC signaling in TEC differentiation and survival.

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Estrogen-like activity in cell signaling of capsaicinoids

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and capsaicinoids (capsaicin (CAP), dihydrocapsaicin (DHCAP), nordihydrocapsaicin (NDHCAP), nonivamide (NV))

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Dual roles for perivascular macrophages in immune-to-brain signaling.

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