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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

ABSTRACT: Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE)

ORGANISM(S): Homo sapiens

PROVIDER: GSE30193 | GEO | 2014/01/01

SECONDARY ACCESSION(S): PRJNA143945

REPOSITORIES: GEO

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Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and Agaricus blazei extract (ABE) Two-condition experiment, E2- or ABE-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

2014-01-01 | E-GEOD-30193 | biostudies-arrayexpress

Estrogen-like activity and dual roles in cell signaling of brefeldin A

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Estrogen-like activity and dual roles in cell signaling of brefeldin A

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and brefeldin A (BFA) Two-condition experiment, E2- or BFA-treated vs. control cells. Two biological replicates, independently grown and harvested. Two replicates per array.

2014-01-01 | E-GEOD-33851 | biostudies-arrayexpress

Estrogen-like activity in cell signaling of capsaicinoids

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and capsaicinoids (capsaicin (CAP), dihydrocapsaicin (DHCAP), nordihydrocapsaicin (NDHCAP), nonivamide (NV))

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Pancreatic adenocarcinoma cell lines were treated with Agaricus blazei Murrill hot water extract (AbE).

Project description:Pancreatic cancer is one of the most aggressive human malignancies with 7.1% five-year survival rate due to late-stage diagnosis and lack of effective treatment. A novel active compound to be useful for treating pancreatic cancer is absolutely demanded. Agaricus blazei (A. blazei) Murrill has been shown to have an anti-cancer activity, however, its specific efficacy and underlying mechanism is poorly understood. Here, we demonstrated that A. blazei hot water extract (AbE) showed significant growth inhibition of cultured pancreatic cancer cells with less suppressive effect on the normal human pancreatic duct epithelial cells. The pancreatic cancer cells committed G0/G1 cell cycle arrest and caspase-dependent apoptosis. Moreover, we uncovered significant alterations of global gene expression in the pancreatic cancer cells by AbE treatment. Signature of alteration of gene expression indicated that AbE induced repression of genes associated with kinetochore function, spindle formation, centromere maintenance, and cyclins and cyclin dependent kinases, which were essential for cell cycle progression. The gene expression analysis also showed upregulation of proapoptotic genes. These results indicate that AbE could be useful for treatment of pancreatic cancer and a good candidate to isolate potent active compound for development of novel drug for pancreatic cancer.

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Estrogen-like activity in cell signaling of lignans

Project description:Comparing the expression profiles of the genes in response to 17b-estradiol (E2) and lignans (sesamin (SE), enterodiol (ED), enterolactone (EL), matairesinol (MR), pinoresinol (PR)).

2017-03-08 | GSE86565 | GEO

Estrogen-like activity and dual roles in cell signaling of an Agaricus blazei Murrill mycelia-dikaryon extract

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Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes.

2010-03-11 | GSE15249 | GEO

Gene expression signatures in uteri from nuclear and membrane effects of Estradiol on Estrogen receptor ERÎ±

Project description:To further study gene expression regulated by 17b-estradiol in uteri, we have employed whole gene microarray profiling to identify genes specifically regulated by the Estrogen receptor ERÎ± localized either at the plasma membrane or in the nucleus. Two mice models have been used, the mice named ERa-AF2Â° (named AF2_KO and on C57BL6/J background) in which 7 aminoacids have been deleted in the AF2 domain and the mice C451A-ERa (named MISS_KO and on C57BL6/N background) mutated for the C451 into Ala on ERa. Control littermates were used for each mutant mice respectively name AF2_WT or MISS_WT. 17b-estradiol induced gene expression in uteri from ovariectomized mice was measured after 6 hours exposure to 0 (PLB) and 8Âµg/kg of 17b-estradiol (E2) injected subcutaneously in castor oil.

2014-07-01 | E-GEOD-53237 | biostudies-arrayexpress

Expression profiling of the genes responding to zearalenone and its analogues using estrogen-responsive genes.

Project description:Comparing the expression profiles of the genes in response to estrogen or 17b-estradiol (E2) and a mycotoxin, zearalenone (ZEA), and its analogues. Keywords: Gene expression profiling Two-condition experiment, E2- or ZEA-treated vs. control cells. 2 to 3 biological replicates, independently grown and harvested. Two to three replicates per array.

2010-09-09 | E-GEOD-15249 | biostudies-arrayexpress

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