Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of human breast cancer patients sensitive to docetaxel

ABSTRACT: These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.

ORGANISM(S): Homo sapiens

SUBMITTER: Chang JC

PROVIDER: S-ECPF-GEOD-350 | biostudies-other | 2003 Aug

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of human breast cancer patients sensitive to docetaxel

Project description:These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.

2008-06-12 | E-GEOD-350 | biostudies-arrayexpress

Transcription profiling of human breast cancer samples

Project description:We measured baseline gene expression profiles for a set of breast tumors. Note: this experiment was modified in June 2008 when the CEL files associated with some hybridizations were changed.

| S-ECPF-TABM-158 | biostudies-other

Transcription profiling of human breast tumors resistant or sensitive to docetaxel treatment

Project description:This SuperSeries is composed of the following subset Series: GSE349: These patients proved resistant to docetaxel treatment, exhibiting residual tumor of 25% or greater remaining volume. Resistant GSE350 These patients were sensitive to docetaxel treatment, exhibiting less than 25% residual tumor.

2007-10-26 | E-GEOD-6434 | biostudies-arrayexpress

Transcription profiling of human breast cancer cell lines

Project description:Total RNA from 46 breast cell lines was labelled using the Illumina TotalPrep RNA Amplification kit (Ambion) following manufacturer's instructions. 1.5 µg of biotin-labelled cRNA were used for each hybridisation on Sentrix Human-6 v1 BeadChips (Illumina, San Diego, CA) following manufacturer's protocol.

| S-ECPF-TABM-827 | biostudies-other

Transcription profiling of MCF-7 Human Breast Cancer Cells

Project description:SOX genes encode a family of high-mobility group transcription factors that play critical roles in organogenesis. Virtually all members of SOX family have been found to be deregulated in tumors of various origins. However, little is known about the cellular and molecular behaviours involved in the oncogenic potential of SOX proteins. Cell culture experiments, tissue analysis, and molecular profiling revealed that SOX2 promotes cell proliferation and tumorigenesis through its transcription regulation of cell cycle related genes in breast cancer cells Experiment Overall Design: To delineate the molecular mechanism underlying the cell proliferation and tumorigenic properties of SOX2, we investigated the gene expression profile in MCF-7 cells. Briefly, MCF-7 cells were transfected with pcDNA3.1 and Human SOX2 expression constructs respectively. 24 hours after transfection, total RNA collected from control and SOX2-overexpressing MCF-7 cells was used to probe Human Genome GeneChip array U133 Plus 2.0

| S-ECPF-GEOD-11330 | biostudies-other

Transcription profiling by array of human breast cancer metastases

Project description:Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Experiment Overall Design: 58 breast cancer metastases from different organs were profiled and compared by the expression level of over 400 cytokines. 29 samples were incuded in this series. 29 others as well as 7 in the present series were profiled on U133A platforms and included in series GSE14018.

| S-ECPF-GEOD-14017 | biostudies-other

Transcription profiling of human growing breast cancer cell lines

Project description:Gene expression analysis on growing breast cancer cell lines. Experiment Overall Design: see Bild, A. et.al.

| S-ECPF-GEOD-3156 | biostudies-other

Transcription profiling of human breast cancer cell lines (23)

Project description:Transcriptional profiling was conducted on RNA from 23 breast cancer cell lines to identify genes whose expression level correlates with sensitivity of particular drug Experiment Overall Design: Baseline gene expression profiling was performed using 23 breast cancer cell lines to identify genomic signatures highly correlated with in vitro sensitivity to a particular drug

| S-ECPF-GEOD-6569 | biostudies-other

Transcription profiling of human pre-malignant breast cancer samples

Project description:Enlargement of normal terminal duct lobular units (TDLUs) by hyperplastic columnar epithelial cells is one of the most common abnormalities of growth in the adult female human breast. These hyperplastic enlarged lobular units (HELUs) are important clinically as the earliest histologically identifiable potential precursor of breast cancer. The causes of the hyperplasia are unknown but may include estrogen-simulated growth mediated by estrogen receptor alpha, which is highly elevated in HELUs and may be fundamental to their development. This study used DNA microarray technology and RNA from microdissected pure epithelial cells to learn more about changes in gene expression and molecular pathways associated with the development of HELUs from TDLUs Experiment Overall Design: Samples for the microarray studies were derived from 8 formalin-fixed paraffin-embedded tissue (FFPET) biopsies containing paired normal TDLUs and well-developed HELUs from non-cancerous adult female human breasts obtained within the past 3 years. Populations of nearly pure (>95%) epithelial cells were isolated from the TDLUs and HELUs in each biopsy (approximately 25,000 cells/sample) by laser capture microdissection (LCM)

| S-ECPF-GEOD-7377 | biostudies-other

Transcription profiling of 51 human breast cancer cell lines

Project description:A cell line comparison experiment for breat cancer 51 cancer cell lines

| S-ECPF-MTAB-7 | biostudies-other