Browse
Submit Data
Databases
API
Help

Dataset Information

18 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer

ABSTRACT: In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene. MCF-7 cells were treates with indicated SERMs in the presence of E2 or vehicle; RNA was isolated and used for preparation of label for 3' expression analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Wardell SE

PROVIDER: S-ECPF-GEOD-35428 | biostudies-other | 2012 Jul

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer

Project description:In this study, we have utilized microarray analysis to directly compare a subset of structurally distinct, clinically relevant SERMs in the presence and absence of estradiol, using a high replicate number (10) to ensure detection of modestly regulated genes. Tested compounds included 4-hydroxytamoxifen, ICI-182,780, Raloxifene, Bazedoxifene and Lasofoxifene.

2012-05-09 | GSE35428 | GEO

Transcriptional profiling of clinically relevant SERMs and SERM/estradiol complexes in a cellular model of breast cancer

2012-05-08 | E-GEOD-35428 | biostudies-arrayexpress

Research resource: Transcriptional profiling in a cellular model of breast cancer reveals functional and mechanistic differences between clinically relevant SERM and between SERM/estrogen complexes.