Ontology highlight
ABSTRACT:
SUBMITTER: Struyf F
PROVIDER: S-EPMC1075719 | biostudies-other | 2005 Mar
REPOSITORIES: biostudies-other
Struyf Frank F Plate Aileen E AE Spear Patricia G PG
Journal of virology 20050301 6
Nectin-1 is an immunoglobulin (Ig)-like entry receptor for herpes simplex virus (HSV). Like other nectins, nectin-1 forms dimers and mediates cell adhesion through interactions with other nectins. We constructed a second-domain deletion mutant of nectin-1 (nectin-1-Delta2) to examine the role of the second Ig-like domain in HSV entry. Nectin-1-Delta2 exhibited a severely reduced ability to mediate HSV entry and accumulated in the endoplasmic reticulum but retained the ability to interact with it ...[more]