Progesterone and oestradiol increase cytosolic Ca2+ in single rat hepatocytes.

ABSTRACT: Progesterone (300-400 microM) and oestradiol (25-200 microM) induce a prompt rise in the cytosolic free Ca2+ concentration (free Ca) in single rat hepatocytes, but testosterone, cortisol and dexamethasone do not. These increases are dependent on the presence of extracellular Ca2+. Both progesterone and oestradiol block phenylephrine-induced free Ca oscillations. These data suggest a certain specificity of the response of free Ca to steroids and may explain some of the non-genomic effects of these steroids on hepatocytes.

SUBMITTER: Sanchez-Bueno A 

PROVIDER: S-EPMC1130631 | biostudies-other | 1991 Nov

REPOSITORIES: biostudies-other