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Acetylene, a mammalian metabolite of 1,1,1-trichloroethane.


ABSTRACT: 1,1,1-Trichloroethane (TCE) is a widely used industrial solvent of low acute toxicity. It is slowly oxidized to trichloroethanol and trichloroacetic acid by cytochrome P-450-dependent mono-oxygenases. Increased inhalative uptake by rats under hypoxia and spin-trapping experiments indicate that TCE is also reductively metabolized to a radical intermediate. Acetylene is formed as a metabolite, suggesting transfer of an additional electron to form the corresponding carbene. Hypoxia and induction of mixed-function mono-oxygenases accelerate the formation of acetylene. Experiments performed in vitro with rat liver microsomal fractions yield analogous results.

SUBMITTER: Durk H 

PROVIDER: S-EPMC1132904 | biostudies-other | 1992 Sep

REPOSITORIES: biostudies-other

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