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Defective phosphorylation of a calmodulin-binding protein in cystic-fibrosis submandibular glands.


ABSTRACT: Calmodulin-binding proteins in fractions purified from human submandibular glands by calmodulin-Sepharose were phosphorylated with [gamma-32P]ATP, in the absence of exogenous protein kinase. The major proteins phosphorylated had molecular masses of 45, 51 and 61 kDa. Phosphorylation was increased by activators of protein kinase C and inhibited by H-7. Phosphorylation of the 61 kDa band was markedly decreased in cystic-fibrosis submandibular glands.

SUBMITTER: Shori DK 

PROVIDER: S-EPMC1133472 | biostudies-other | 1989 Oct

REPOSITORIES: biostudies-other

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