How to draw kinetic barrier diagrams for enzyme-catalysed reactions.
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ABSTRACT: A modified way to construct kinetic barrier diagrams is presented. Although the diagram superficially resembles a free-energy profile, it is independent of any conception derived from transition-state theory. Some simple calculations referring to the lactate dehydrogenase turnover reaction at equilibrium demonstrate self-consistency of the diagram and its direct relevance to the results of numerical simulations of the detailed course of enzyme-catalysed reactions.
SUBMITTER: Sudi J
PROVIDER: S-EPMC1151175 | biostudies-other | 1991 May
REPOSITORIES: biostudies-other
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