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Human renin in transgenic mouse kidney is localized to juxtaglomerular cells.

ABSTRACT: To examine whether expression of human renin in the transgenic mouse kidney is regulated in a cell-specific manner, we have characterized monoclonal antibodies against human renin and determined the renin-production site by immunohistochemistry. By using a monoclonal antibody specific for human renin, A6-11-6, we demonstrated that human renin in the transgenic mouse kidney is localized to the juxtaglomerular cells of afferent arterioles.

SUBMITTER: Fukamizu A

PROVIDER: S-EPMC1151386 | biostudies-other | 1991 Sep

REPOSITORIES: biostudies-other

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