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Antizyme to ornithine decarboxylase is present in the liver of starved rats.


ABSTRACT: Antizyme to ornithine decarboxylase (ODC) and ODC-antizyme complex were both present in liver cytosols of starved rats. The antizyme was identified by its molecular weight, kinetic properties, formation of a complex with ODC, and reversal of its inhibition by antizyme inhibitor. The average amount of antizyme in liver cytosols of starved rats was 0.1 unit/mg of protein, roughly corresponding to basal hepatic ODC activity in rats fed ad libitum. The presence of ODC-antizyme complex was detected by using antizyme inhibitor. These results indicate that antizyme participates in the regulation of ODC activity in vivo under physiological conditions.

SUBMITTER: Fujita K 

PROVIDER: S-EPMC1153372 | biostudies-other | 1984 Mar

REPOSITORIES: biostudies-other

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