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A protein inhibitor of phosphofructokinase from the mucosa of rat small intestine. A mechanism for the regulation of glycolysis that is independent of glucose.


ABSTRACT: A protein inhibitor of phosphofructokinase was detected by the chromatography on Sephadex G-100 of crude mucosal extracts prepared from the small intestine of starved rats. Addition of the protein inhibitor to extracts from fed rats increased the K0.5 of phosphofructokinase for fructose 6-phosphate to that for starved rats. The protein inhibitor provides a mechanism for the hormonal regulation of glycolysis independently of glucose supply.

SUBMITTER: Kellett GL 

PROVIDER: S-EPMC1153666 | biostudies-other | 1984 Jun

REPOSITORIES: biostudies-other

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