A cysteine proteinase secreted from human breast tumours is immunologically related to cathepsin B.

ABSTRACT: The stable cathepsin B-like cysteine (thiol) proteinase secreted from human breast tumours in culture was shown to be destabilized by mercurial compounds. After such treatment the enzyme cross-reacts in a radioimmunoassay with a monospecific antiserum to human liver cathepsin B. It is suggested that the secreted enzyme may be a precursor form of lysosomal cathepsin B.

SUBMITTER: Recklies AD 

PROVIDER: S-EPMC1153912 | biostudies-other | 1982 Dec

REPOSITORIES: biostudies-other