Interaction of the pBR 322-coded RTEM beta-lactamase with substrates. Evidence for specific conformational transitions.
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ABSTRACT: The rate of inactivation of RTEM-1 beta-lactamase by Pronase is accelerated by class A ('resistant') penicillins. Other substrates (class S penicillin and cephalosporins) protect against the inactivation. Cefoxitin, a semi-synthetic cephamycin, induces a more extensive, hysteretic response. In its presence the enzyme is inactivated by trypsin as well as by Pronase.
SUBMITTER: Citri N
PROVIDER: S-EPMC1163661 | biostudies-other | 1982 Feb
REPOSITORIES: biostudies-other
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