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Effect of 2-allyl-2-isopropylacetamide on poly(adenylic acid)-containing ribonucleic acid.


ABSTRACT: A single administration of 2-allyl-2-isopropylacetamide, a porphyrinogenic drug, enhanced the 32P-labelling of nucleoplasmic as well as cytoplasmic poly(A)-containing RNA in rat liver. The synthesis of total microsomal RNA is only marginally increased under these conditions. The drug enhances the labelling of a variety of cytoplasmic poly(A)-containing RNA species, and this effect is counteracted by the simultaneous administration of haemin. 2-Allyl-2-isopropylacetamide also enhanced the release of RNA from the nucleus to the cytoplasm.

SUBMITTER: Sardana MK 

PROVIDER: S-EPMC1163956 | biostudies-other | 1976 Aug

REPOSITORIES: biostudies-other

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