Identity of rat kidney histidine-pyruvate aminotransferase with glutamine-oxo acid aminotransferase.

ABSTRACT: Histidine-pyruvate aminotransferase and glutamine-phenylpyruvate aminotransferase were purified from rat kidney by the same procedure. The ratio of the two activities remained constant during purification and was unchanged by a variety of treatments of the purified enzyme. Glutamine was found to act as a competitive inhibitor of histidine-pyruvate aminotransferase. These results suggest that rat kidney histidine-pyruvate aminotransferase is identical with glutamine-oxo acid aminotransferase. Identity of the two enzymes in other tissues of rats is discussed.

SUBMITTER: Noguchi T 

PROVIDER: S-EPMC1164486 | biostudies-other | 1977 Jan

REPOSITORIES: biostudies-other