The mechanism of C-4 demethylation during cholesterol biosynthesis.
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ABSTRACT: The conversion of 4,4-dimethylcholest-7-enol into 4alpha-methylcholest-7-enol by rat liver microsomal preparations involves the decarboxylation of a sterol 3-oxo-4alpha-carboxylic acid. By using an (18)O-labelled substrate it was shown that this decarboxylation does not involve a Schiff-base intermediate.
SUBMITTER: Wilton DC
PROVIDER: S-EPMC1165609 | biostudies-other | 1975 Jul
REPOSITORIES: biostudies-other
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