Ontology highlight
ABSTRACT:
SUBMITTER: Amicone L
PROVIDER: S-EPMC1169653 | biostudies-other | 1997 Feb
REPOSITORIES: biostudies-other
The EMBO journal 19970201 3
Hepatocyte growth factor induces proliferation, motility and differentiation of epithelial cells through the tyrosine kinase receptor encoded by the MET protooncogene. The cytoplasmic portion of Met (referred to as cyto-Met) is activated but only weakly transforming. In order to determine the effect of activated Met on hepatocytes, we have targeted truncated Met expression to the liver by incorporating the cDNA into a vector carrying the entire human alpha-1-antitrypsin transcriptional unit. Tra ...[more]