Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC1170354 | biostudies-other | 1998 Jan
REPOSITORIES: biostudies-other
Wang J J Lim K K Smolyar A A Teng M M Liu J J Tse A G AG Liu J J Hussey R E RE Chishti Y Y Thomson C T CT Sweet R M RM Nathenson S G SG Chang H C HC Sacchettini J C JC Reinherz E L EL
The EMBO journal 19980101 1
Each T cell receptor (TCR) recognizes a peptide antigen bound to a major histocompatibility complex (MHC) molecule via a clonotypic alphabeta heterodimeric structure (Ti) non-covalently associated with the monomorphic CD3 signaling components. A crystal structure of an alphabeta TCR-anti-TCR Fab complex shows an Fab fragment derived from the H57 monoclonal antibody (mAb), interacting with the elongated FG loop of the Cbeta domain, situated beneath the Vbeta domain. This loop, along with the part ...[more]