An actively retrotransposing, novel subfamily of mouse L1 elements.
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ABSTRACT:
SUBMITTER: Naas TP
PROVIDER: S-EPMC1170408 | biostudies-other | 1998 Jan
REPOSITORIES: biostudies-other
Publications
An actively retrotransposing, novel subfamily of mouse L1 elements.
Naas T P TP DeBerardinis R J RJ Moran J V JV Ostertag E M EM Kingsmore S F SF Kingsmore S F SF Seldin M F MF Hayashizaki Y Y Martin S L SL Kazazian H H HH
The EMBO journal 19980101 2
Retrotransposition of LINEs and other retroelements increases repetition in mammalian genomes and can cause deleterious mutations. Recent insertions of two full-length L1s, L1spa and L1Orl, caused the disease phenotypes of the spastic and Orleans reeler mice respectively. Here we show that these two recently retrotransposed L1s are nearly identical in sequence, have two open reading frames and belong to a novel subfamily related to the ancient F subfamily. We have named this new subfamily TF (fo ...[more]
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