Ontology highlight
ABSTRACT:
SUBMITTER: Gerber A
PROVIDER: S-EPMC1170807 | biostudies-other | 1998 Aug
REPOSITORIES: biostudies-other
Gerber A A Grosjean H H Melcher T T Keller W W
The EMBO journal 19980801 16
We have identified an RNA-specific adenosine deaminase (termed Tad1p/scADAT1) from Saccharomyces cerevisiae that selectively converts adenosine at position 37 of eukaryotic tRNAAla to inosine. The activity of purified recombinant Tad1p depends on the conformation of its tRNA substrate and the enzyme was found to be inactive on all other types of RNA tested. Mutant strains in which the TAD1 gene is disrupted are viable but lack Tad1p enzyme activity and their tRNAAla is not modified at position A ...[more]