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Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

ABSTRACT: In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim-3 are constitutively expressed in the hippocampus and Pim-3 expression is similarly induced by synaptic activity. Thus, expression of Pim-1 is required for LTP. Its level of expression and, consequently, its capacity to phosphorylate target proteins in dendritic and nuclear compartments of stimulated neurons might be a determining factor for the establishment of long-lasting changes in synaptic strength.

SUBMITTER: Konietzko U

PROVIDER: S-EPMC1171416 | biostudies-other | 1999 Jun

REPOSITORIES: biostudies-other

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Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

Konietzko U U Kauselmann G G Scafidi J J Staubli U U Mikkers H H Berns A A Schweizer M M Waltereit R R Kuhl D D

The EMBO journal 19990601 12

In animals and several cellular models of synaptic plasticity, long-lasting changes in synaptic strength are dependent on gene transcription and translation. Here we demonstrate that Pim-1, a serine/threonine kinase closely related to Pim-2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long-term potentiation (LTP). Mice deficient for Pim-1 show normal synaptic transmission and short-term plasticity. However, they fail to consolidate enduring LTP even though Pim-2 and Pim ...[more]

PMID: 10369676

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