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Conversion of pepsinogen into pepsin is not a one-step process.

ABSTRACT: By incubation of pepsinogen with pepstatin at pH2.5, the first 'active' protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin.

SUBMITTER: Dykes CW 

PROVIDER: S-EPMC1172551 | biostudies-other | 1976 Jan

REPOSITORIES: biostudies-other

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