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Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication).


ABSTRACT: The activity of pyruvate dehydrogenase was assayed in extracts of rat hearts perfused in vitro with media containing glucose and insulin+/-acetate+/-dichloroacetate. Dichloroacetate (100mum, 1mm or 10mm) increased the activity of pyruvate dehydrogenase in perfusions with glucose or glucose+acetate. Evidence is given that dichloroacetate may facilitate the conversion of pyruvate dehydrogenase from an inactive (phosphorylated) form into an active (dephosphorylated) form.

SUBMITTER: Whitehouse S 

PROVIDER: S-EPMC1177854 | biostudies-other | 1973 Jun

REPOSITORIES: biostudies-other

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