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The stereochemistry of beta-lactam formation in cephalosporin biosynthesis.


ABSTRACT: 3H and 14C from (2R,3S)[U-14C,3-3H1]cysteine and (2R,3R)-[U-14C,2,3-3H2]cysteine were incorporated into cephalosporin C by Cephalosporium acremonium. Analysis of the radioactive cephalosporin C indicated that the formation of its beta-lactam ring occurs stereospecifically and with retention of configuration at C-3 of cysteine.

SUBMITTER: Huddleston JA 

PROVIDER: S-EPMC1183844 | biostudies-other | 1978 Mar

REPOSITORIES: biostudies-other

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