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String of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis.

ABSTRACT: The first allele of string of pearls (sop) was isolated as a recessive female sterile mutant in a P element enhancer trap screen. Oogenesis in homozygous sop females arrests at approximately stage 5. In addition, homozygous flies of both sexes have Minute-like characteristics that include reduced bristles, delayed development and larval lethality. sop maps to 30D/E on chromosome 2L and encodes the Drosophila homolog of eukaryotic ribosomal protein S2. The gene is present in a single copy in the Drosophila genome and the level of mRNA present in mutant animals is reduced. The identification of a mutant allele that blocks development at a mid-stage of oogenesis may indicate that sop has a specific developmental role during oogenesis in addition to its general role in protein synthesis as a component of the small ribosomal subunit.

SUBMITTER: Cramton SE

PROVIDER: S-EPMC1206051 | biostudies-other | 1994 Aug

REPOSITORIES: biostudies-other

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string of pearls encodes Drosophila ribosomal protein S2, has Minute-like characteristics, and is required during oogenesis.

Cramton S E SE Laski F A FA

Genetics 19940801 4

The first allele of string of pearls (sop) was isolated as a recessive female sterile mutant in a P element enhancer trap screen. Oogenesis in homozygous sop females arrests at approximately stage 5. In addition, homozygous flies of both sexes have Minute-like characteristics that include reduced bristles, delayed development and larval lethality. sop maps to 30D/E on chromosome 2L and encodes the Drosophila homolog of eukaryotic ribosomal protein S2. The gene is present in a single copy in the ...[more]

PMID: 7982558

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