Unknown

Dataset Information

0

CONJUGATIONS WITH GLUTATHIONE. THE ENZYMIC CONJUGATION OF SOME CHLOROCYCLOHEXENES.


ABSTRACT: 1. alpha-3,4,5,6-Tetrachlorocyclohex-1-ene and gamma-2,3,4,5,6-pentachlorocyclohex-1-ene are conjugated with glutathione in vitro by a rat-liver enzyme that is probably glutathione S-aryltransferase. 2. Chlorocyclohexane and the alpha-, beta-, gamma- and delta-isomers of hexachlorocyclohexane were not substrates for rat-liver glutathione S-aryltransferase. 3. Glutathione-S-aryltransferase activity was present in tissue preparations of houseflies of insecticide-resistant and -susceptible strains. More activity was found in a dieldrin-resistant strain of houseflies fed on dieldrin than in either a dieldrin-resistant strain not fed on dieldrin or a control strain of dieldrin-susceptible houseflies. 4. Housefly soluble supernatant preparations converted S-(2-chloro-4-nitrophenyl)glutathione into the corresponding cysteine and mercapturic acid derivatives.

SUBMITTER: SIMS P 

PROVIDER: S-EPMC1215189 | biostudies-other | 1965 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC4205000 | biostudies-literature
| S-EPMC9104575 | biostudies-literature
| S-EPMC2941764 | biostudies-literature
| S-EPMC1206427 | biostudies-other
| S-EPMC3850785 | biostudies-literature
| S-EPMC9243339 | biostudies-literature
| S-EPMC1132114 | biostudies-other
| S-EPMC1218576 | biostudies-other
| S-EPMC1179365 | biostudies-other
| S-EPMC5622914 | biostudies-literature