Unknown

Dataset Information

0

Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts.

ABSTRACT: PtdIns(3,5)P2 is identified as the product of an agonist-independent, wortmannin-sensitive pathway in resting mouse cells. Results are presented here to indicate that PtdIns(3,5)P2 is formed by phosphorylation of PtdIns3P at the D-5 position, and they suggest that relatively constant cellular levels of PtdIns3P and PtdIns(3, 5)P2 are maintained by the concerted action of PtdIns3P 5-kinase and PtdIns(3,5)P2 5-phosphatase. These studies imply a novel mechanism for the action of PtdIns-specific phosphoinositide 3-hydroxykinases in mammalian cells.

SUBMITTER: Whiteford CC 

PROVIDER: S-EPMC1218360 | biostudies-other | 1997 May

REPOSITORIES: biostudies-other

Json Xml

Similar Datasets

Unknown Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) potentiates cardiac contractility via activation of the ryanodine receptor.
| S-EPMC3001011 | biostudies-literature
Unknown Depolarization increases phosphatidylinositol (PI) 4,5-bisphosphate level and KCNQ currents through PI 4-kinase mechanisms.
| S-EPMC2843189 | biostudies-literature
Unknown Phosphatidylinositol 4,5-bisphosphate is regenerated by speeding of the PI 4-kinase pathway during long PLC activation.
| S-EPMC7671494 | biostudies-literature
Unknown Phosphatidylinositol 3,5-bisphosphate: low abundance, high significance.
| S-EPMC3906640 | biostudies-literature
Unknown An intramolecular interaction within the lipid kinase Fab1 regulates cellular phosphatidylinositol 3,5-bisphosphate lipid levels.
| S-EPMC5385934 | biostudies-literature
Unknown Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.
| S-EPMC2173454 | biostudies-literature
Unknown Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate.
| S-EPMC2043547 | biostudies-literature
Unknown The ML1Nx2 Phosphatidylinositol 3,5-Bisphosphate Probe Shows Poor Selectivity in Cells.
| S-EPMC4604148 | biostudies-literature
Unknown Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.
| S-EPMC3876232 | biostudies-literature
Unknown Eisosomes Regulate Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2) Cortical Clusters and Mitogen-activated Protein (MAP) Kinase Signaling upon Osmotic Stress.
| S-EPMC4646250 | biostudies-literature