Acyl-CoA binding protein is an essential protein in mammalian cell lines.
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ABSTRACT: In the present work, small interference RNA was used to knock-down acyl-CoA binding protein (ACBP) in HeLa, HepG2 and Chang cells. Transfection with ACBP-specific siRNA stopped growth, detached cells from the growth surface and blocked thymidine and acetate incorporation. The results show that depletion of ACBP in mammalian cells results in lethality, suggesting that ACBP is an essential protein.
SUBMITTER: Faergeman NJ
PROVIDER: S-EPMC1223051 | biostudies-other | 2002 Dec
REPOSITORIES: biostudies-other
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