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Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus.


ABSTRACT: Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.

SUBMITTER: Hayden MK 

PROVIDER: S-EPMC1248493 | biostudies-other | 2005 Oct

REPOSITORIES: biostudies-other

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Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus.

Hayden M K MK   Rezai K K   Hayes R A RA   Lolans K K   Quinn J P JP   Weinstein R A RA  

Journal of clinical microbiology 20051001 10


Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates. ...[more]

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