Ontology highlight
ABSTRACT:
SUBMITTER: Nakada D
PROVIDER: S-EPMC1266421 | biostudies-other | 2005 Nov
REPOSITORIES: biostudies-other
Nakada Daisuke D Hirano Yukinori Y Tanaka Yuya Y Sugimoto Katsunori K
Molecular biology of the cell 20050907 11
The large protein kinases, ataxia-telangiectasia mutated (ATM) and ATM-Rad3-related (ATR), coordinate the cellular response to DNA damage. In budding yeast, ATR homologue Mec1 plays a central role in DNA damage signaling. Mec1 interacts physically with Ddc2 and functions in the form of the Mec1-Ddc2 complex. To identify proteins interacting with the Mec1-Ddc2 complex, we performed a modified two-hybrid screen and isolated RFA1 and RFA2, genes that encode subunits of replication protein A (RPA). ...[more]