Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
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ABSTRACT:
SUBMITTER: Ober C
PROVIDER: S-EPMC1288105 | biostudies-other | 2000 Feb
REPOSITORIES: biostudies-other
Publications
Variation in the interleukin 4-receptor alpha gene confers susceptibility to asthma and atopy in ethnically diverse populations.
Ober C C Leavitt S A SA Tsalenko A A Howard T D TD Hoki D M DM Daniel R R Newman D L DL Wu X X Parry R R Lester L A LA Solway J J Blumenthal M M King R A RA Xu J J Meyers D A DA Bleecker E R ER Cox N J NJ
American journal of human genetics 20000201 2
After a genomewide screen in the Hutterites was completed, the IL4RA gene was examined as the 16p-linked susceptibility locus for asthma and atopy. Seven known variants and one novel variant, representing all nonsynonymous substitutions in the mature protein, were examined in the Hutterites; on the basis of studies in the Hutterites, outbred white, black, and Hispanic families were genotyped for selected markers. All population samples showed evidence of association to atopy or to asthma (P valu ...[more]
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