Ontology highlight
ABSTRACT:
SUBMITTER: Avdonin V
PROVIDER: S-EPMC1300977 | biostudies-other | 2000 Aug
REPOSITORIES: biostudies-other
Avdonin V V Nolan B B Sabatier J M JM De Waard M M Hoshi T T
Biophysical journal 20000801 2
Maurotoxin (alpha-KTx6.2) is a toxin derived from the Tunisian chactoid scorpion Scorpio maurus palmatus, and it is a member of a new family of toxins that contain four disulfide bridges (, Eur. J. Biochem. 254:468-479). We investigated the mechanism of the maurotoxin action on voltage-gated K(+) channels expressed in Xenopus oocytes. Maurotoxin blocks the channels in a voltage-dependent manner, with its efficacy increasing with greater hyperpolarization. We show that an amino acid residue in th ...[more]