Ontology highlight
ABSTRACT:
SUBMITTER: Lynch TW
PROVIDER: S-EPMC1302451 | biostudies-other | 2002 Jan
REPOSITORIES: biostudies-other
Biophysical journal 20020101 1 Pt 1
The fundamental processes by which proteins recognize and bind to nucleic acids are critical to understanding cellular function. To explore the factors involved in protein-DNA recognition, we used hydrostatic pressure to perturb the binding of the BamHI endonuclease to cognate DNA, both in experiment and in molecular dynamic simulations. A new technique of high-pressure gel mobility shift analysis was used to test the effects of elevated hydrostatic pressure on the binding of BamHI to its cognat ...[more]