Ontology highlight
ABSTRACT:
SUBMITTER: Clancy L
PROVIDER: S-EPMC1312398 | biostudies-other | 2005 Dec
REPOSITORIES: biostudies-other
Clancy Lauren L Mruk Karen K Archer Kristina K Woelfel Melissa M Mongkolsapaya Juthathip J Screaton Gavin G Lenardo Michael J MJ Chan Francis Ka-Ming FK
Proceedings of the National Academy of Sciences of the United States of America 20051130 50
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a cytokine with potential therapeutic value against cancers because of its selective cytotoxicity to many transformed, but not normal, cells. The "decoy receptors" TRAIL-R3 (TR3) and TRAIL-R4 (TR4) were believed to negatively regulate TRAIL-induced cytotoxicity by competing for ligand binding with TRAIL-R1 (TR1) and TRAIL-R2 (TR2). Here, we show that inhibition of TRAIL-induced apoptosis by TR4 critically depends on its ass ...[more]