Ontology highlight
ABSTRACT:
SUBMITTER: Pasternack RF
PROVIDER: S-EPMC1367090 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Biophysical journal 20051104 3
The kinetics of insulin-based amyloid gel formation has been studied using extinction and fluorescence detection. The process is treated as autocatalytic, and the kinetic profiles are fit using a nonconventional analysis involving a time-dependent rate constant (factor): k(t) = k(o) + k(c)(k(c)t)(n). The dependence of the kinetic parameters on initial solution conditions of concentration, pH, and ionic strength has been investigated. A mechanism is proposed in which the rate-determining step inv ...[more]