P53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
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ABSTRACT:
SUBMITTER: Arias-Lopez C
PROVIDER: S-EPMC1369244 | biostudies-other | 2006 Feb
REPOSITORIES: biostudies-other
Publications
p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene.
Arias-Lopez Carmen C Lazaro-Trueba Iciar I Kerr Peter P Lord Christopher J CJ Dexter Tim T Iravani Marjan M Ashworth Alan A Silva Augusto A
EMBO reports 20060201 2
DNA repair by homologous recombination is involved in maintaining genome stability. Previous data report that wild-type p53 suppresses homologous recombination and physically interacts with Rad51. Here, we show the in vivo binding of wild-type p53 to a p53 response element in the promoter of Rad51 and the downregulation of Rad51 messenger RNA and protein by wild-type p53, favoured by DNA damage. Moreover, wild-type p53 inhibits Rad51 foci formation in response to double-strand breaks, whereas p5 ...[more]
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