Ontology highlight
ABSTRACT:
SUBMITTER: Mathews DH
PROVIDER: S-EPMC1369867 | biostudies-other | 1999 Nov
REPOSITORIES: biostudies-other
Mathews D H DH Burkard M E ME Freier S M SM Wyatt J R JR Turner D H DH
RNA (New York, N.Y.) 19991101 11
A computer program, OligoWalk, is reported that predicts the equilibrium affinity of complementary DNA or RNA oligonucleotides to an RNA target. This program considers the predicted stability of the oligonucleotide-target helix and the competition with predicted secondary structure of both the target and the oligonucleotide. Both unimolecular and bimolecular oligonucleotide self structure are considered with a user-defined concentration. The application of OligoWalk is illustrated with three com ...[more]