Ontology highlight
ABSTRACT:
SUBMITTER: Michiels PJ
PROVIDER: S-EPMC1370051 | biostudies-other | 2000 Dec
REPOSITORIES: biostudies-other
Michiels P J PJ Schouten C H CH Hilbers C W CW Heus H A HA
RNA (New York, N.Y.) 20001201 12
The cleavage site of the Neurospora VS RNA ribozyme is located in a separate hairpin domain containing a hexanucleotide internal loop with an A-C mismatch and two adjacent G-A mismatches. The solution structure of the internal loop and helix la of the ribozyme substrate hairpin has been determined by nuclear magnetic resonance (NMR) spectroscopy. The 2 nt in the internal loop, flanking the cleavage site, a guanine and adenine, are involved in two sheared G.A base pairs similar to the magnesium i ...[more]