Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara T
PROVIDER: S-EPMC1370070 | biostudies-other | 2001 Jan
REPOSITORIES: biostudies-other
Fujiwara T T Ito K K Nakamura Y Y
RNA (New York, N.Y.) 20010101 1
Ribosome recycling factor (RRF) is required for disassembly of the posttermination complex of the ribosome after release of polypeptides. The crystal structure of RRF resembles a tRNA shape, with an architecturally different flexibility compared with tRNA, but its structure-and-function relationships are unknown. We here found that an RRF variant defective in ribosome binding regains the binding capacity through 20 independent secondary changes occurring in three topologically distinct regions o ...[more]